The association of proteins into stable complexes is central to an array of biological processes. Predicting the structures of and understanding the mechanisms by which proteins associate into these complexes are outstanding challenges in the field of molecular biology. Advances to our understanding could also have important implications for drug discovery efforts involving protein-protein complexes, a large and important class of therapeutic targets where progress toward the clinic, especially for small-molecule drugs, has been challenging. To study protein-protein association, we have developed an approach called tempered binding that combines long timescale atomic-level molecular dynamics simulations with simulated Hamiltonian tempering. We will describe the results of tempered binding simulations in which proteins repeatedly associate into, and dissociate from, their crystallographically-determined complex structures, and discuss insights into protein-protein association mechanisms revealed by these simulations.
March 27, 2023
Family of Nobel Laureate Gertrude Elion Donates Medal, Papers to Hunter
Hunter College received the 1988 Nobel Prize in Medicine won by biochemist, pharmacologist, and Hunter College alumna Gertrude Elion ’37.
Apr 4, 2023
Patrick Gaspard - Public Policy and Presidential Politics in America
With 20 months to go until the 2024 presidential election, both parties are staking out policy positions on a number of issues hoping to connect ...