Dr. Paul Feinstein is a Professor in the Department of Biological Sciences.
See Contact DetailsTo understand how Humans perceive odors.
To understand how OR singular gene choice occurs in olfactory neurons.
To understand how OR dependent axonal identity occurs
Uncoupling stimulus specificity and glomerular position in the mouse olfactory system. Mol Cell Neurosci. 2012
To understand how many GPCRs traffic to the plasma membrane and why ORs do not.
To understand the role of trigeminal neurons in whisker function.
To understand the pluripotent state of embryonic stem cells.
37) R. Higuchi-Sanabria, E.J. Garcia, D. Tomoiaga, E.L. Munteanu, P. Feinstein,P, and L.A. Pon. (2016)
Characterization of Fluorescent Proteins for Three- and Four-Color Live-Cell Imaging in S. cerevisiae.
PLoS One 2016 Jan 4;11(1):e0146120. doi: 10.1371/journal.pone.0146120.
Citations 0
36) S. Jamet, J. Bubnell, P. Pfister, D. Tomoiaga, M.E. Rogers, and P. Feinstein.(2015)
In vitro Mutational Analysis of the β2 Adrenergic Receptor, an in vivo Surrogate Odorant Receptor
PLoS One. 2015 Oct 29;10(10):e0141696. doi: 10.1371/journal.pone.0141696
Citations 1
35) J. Bubnell, S. Jamet, D.Tomoiaga, C.D’Hulst, K. Krampis, J. Zhang, T. Bozza and P. Feinstein. (2015)
In vitro Mutational and Bioinformatics Analysis of the M71 Odorant Receptor and its Superfamily.
PLoS One. 2015 Oct 29;10(10):e0141712. doi: 10.1371/journal.pone.0141712
Citations 1
34) D. Bakalar, J. Tamaiev, H. P. Zeigler, and P. Feinstein. (2015)
Abolition of lemniscal barrellette patterning in Prxxl1 knockout mice: effects upon ingestive behavior.
Somatosens Mot Res. 2015 Dec;32(4):236-48. doi: 10.3109/08990220.2015.1086327
Citations 0
33) J. Bubnell, Patrick Pfister, Maria L. Sapar, Matt Rogers, and P. Feinstein. (2013)
Beta2adrenergic Fluorescent protein fusions traffic to plasma membrane and retain functionality.
PLoS One. 2013 Sep 23;8(9):e74941. doi: 10.1371/journal.pone.0074941.
Citations 6
32) C. D’Hulst, I. Paranova, D. Tomoiaga, M. L. Sapar, and P. Feinstein. (2013)
Fast quantitative real-time PCR based screening for common chromosomal aneuploidies in mouse embryonic stem cells.
Stem Cell Reports, Volume 1, Issue 4, 350-359, 26 September 2013
Citations 1
31) J. Zhang, R. Pacifico, D. Cawley, P.Feinstein and T. Bozza. (2013)
Ultrasensitive detection of amines by a trace amine-associated receptor.
J Neurosci. Feb 13;33(7):3228-39. doi: 10.1523/JNEUROSCI.4299-12.2013.
Citations 31
30) J. Zhang, G, Huang, A. Dewan, P. Feinstein, T. Bozza. (2012)
Uncoupling stimulus specificity and glomerular position in the mouse olfactory system.
Mol Cell Neurosci. 2012 Aug; 51,79-88. Epub 2012 Aug 21
Citations 10
29) A.Vassalli, P. Feinstein, and P. Mombaerts (2010)
Homeodomain binding motifs modulate the probability of odorant receptor gene choice in transgenic mice.
Mol Cell Neurosci. 2011 Feb;46(2):381-96. Epub 2010 Nov 26.
Citations 19
28) L. Capello, D. Roppolo, V.P. Jungo, P. Feinstein and I. Rodriguez. (2009)
A common gene exclusion mechanism used by two chemosensory systems.
Eur J Neurosci. 2009 Feb;29(4):671-8. Epub 2009 Feb 6
Citations 7
27) T. Bozza, A. Vassalli, S. Fuss, JJ. Zhang, B. Weiland, R. Pacifico, P. Feinstein and P. Mombaerts. (2009)
Mapping of ClassI and ClassII odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse.
Neuron 61: 1-13
Citations 95
26) A. Walz, P. Feinstein, M. Khan and P. Mombaerts. (2007)
Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F.
Develelopment 134: 4063-4072
Citations 46
25) P. Mombaerts and P. Feinstein. (2005)
Axonal Wiring through Odorant Receptors.
Brain Function. Dahlem Workshop Report 93. Cambride, MA: The MIT Press. Book
24) A. Rothman, P. Feinstein, J. Hirota, and P. Mombaerts. (2005)
The Promoter of the Mouse M71 Odorant Receptor.
Mol. Cell. Neurosci. 28: 535– 546 (doi:10.1016/j.mcn.2004.11.006)
Citations 58
23) P. Feinstein, T. Bozza, I. Rodriguez, A. Vassalli, and P. Mombaerts (2004)
Axon Guidance of Mouse Olfactory Sensory Neurons by Odorant Receptors and The β2 Adrenergic Receptor.
Cell 117: 833-846
Citations 220
22) P. Feinstein and P. Mombaerts (2004)
A Contextual Model for Axonal Sorting into Glomeruli of the Mouse Olfactory System.
Cell 117: 817-831
Citations 237
21) D.J. Zou, P. Feinstein, A.L.Rivers, G.A. Mathews, A. Kim, C.A. Greer, P. Mombaerts, and S. Firestein (2004)
Postnatal refinement of peripheral olfactory projections.
Science 304: 1976-1979.
Citations 161
20) J. Li, T. Ishii, P. Feinstein, and P. Mombaerts (2004)
Odorant Receptor Gene Choice is Reset by Nuclear Transfer from Mouse Olfactory Sensory Neurons.
Nature 428: 393-399
Citations 208
19) S.S. Wang, J.W. Lewcock, P. Feinstein, P. Mombaerts, and R.R. Reed (2004)
Genetic Disruptions of O/E2 and O/E3 Genes Reveal Involvement in Olfactory Neuron Projection.
Development 131: 1377-1388
Citations 88
18) L. Belluscio, C. Lodovichi , P. Feinstein, P. Mombaerts and L. Katz (2002)
Odorant Receptors Organize Local Circuitry in the Mouse Olfactory Bulb.
Nature 419: 296-300
Citations 131
17) A.Vassalli, A. Rothman, P. Feinstein, M. Zapotocky and P. Mombaerts (2002)
Minigenes Impart Odorant Receptor-Specific Axon Guidance in the Olfactory Bulb.
Neuron 35: 681-696
Citations 187
16) T. Bozza, P. Feinstein, C. Zheng and P. Mombaerts (2002)
Odorant Receptor Expression Defines Functional Units in the Moue Olfactory System.
Journal of Neuroscience 22(8): 3033-43
Citations 313
15) H.B. Treloar, P. Feinstein, P. Mombaerts anc C.A. Greer (2002)
Specificity of Glomerular Targeting by Olfactory Sensory Axons.
Journal of Neuroscience 22(7): 2469-77
Citations 161
14) S.M. Potter*, C. Zheng, D.S*. Koos*, P. Feinstein*, S.E. Fraser* and P. Mombaerts*
(2001) Structure and Emergence of Specific Olfactory Glomeruli in the Mouse.
Journal of Neuroscience 21(24): 9713-23 *All authors contributed equally
Citations 238
13) A.C. Perry, A. Rothman, J.I. de las Heras, P. Feinstein, P. Mombaerts, H.J. Cooke and T. Wakayama (2001)
Efficient Metaphase II Transgenesis with Different Transgene Archetypes.
Nature Biotechnology 19(11): 1071-3
Citations 66
12) L. Feiner, A.L. Webber, C. B. Brown, M. M. Lu, L. Jia, P. Feinstein, P. Mombaerts, J.A. Epstein, J. Raper (2001)
Targeted Disruption of Semaphorin 3C Leads to Persistent Truncus Arteriosus and Aortic Arch Interruption.
Development 128(16): 3061-70
Citations 247
11) P. Cohen, C. Zhao, X. Cai, J.M. Montez, S.C. Rohani, P. Feinstein, P. Mombaerts and J.M. Friedman. (2001)
Selective Deletion of Leptin Receptor in Neurons Leads to Obesity.
Journal of Clinical Investigation 108(8): 1113-21
Citations 523
10) S. Xie, P. Feinstein and P. Mombaerts (2000)
Characterization of a Cluster Comprising ~100 Odorant Receptor Genes in Mouse.
Mammalian Genome 11:1070-1078
Citations 31
9) J. Strotmann, S. Conzelmannn, A. Beck, P. Feinstein, H. Breer and P. Mombaerts (2000)
Local Permutations in Glomerular Array of the Mouse Olfactory Bulb.
Journal of Neuroscience 20(18): 6927-6938
Citations 181
8) C. Zheng, P. Feinstein, T. Bozza, I. Rodriguez and P. Mombaerts (2000)
Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit.
Neuron 26:81-91.
Citations 204
7) J. Strotmann, R. Hoppe, S. Conzelmann, P. Feinstein, P. Mombaerts and H. Breer. (1999)
Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization.
Gene 236:281-291
Citations 42
6) I. Rodriguez, P. Feinstein and P. Mombaerts (1999)
Variable Patterns of Axonal Projections of Sensory Neurons in the Mouse Vomeronasal System.
Cell 97:199-208
Citations 327
5) P.G. Feinstein, K. Kornfeld, D. S. Hogness and R. S. Mann (1995)
Identification of Homeotic Target Genes in Drosophila melanogaster Including nervy, a Proto-Oncogene Homologue.
Genetics 140:573-586
Citations 115
4) L. R. Levin, P-L Han, P.M. Hwang, P. G. Feinstein, R.L. Davis and R.R. Reed (1992)
The Drosophila Learning and Memory Gene rutabaga Encodes a Ca+/Calmodulin-Responsive Adenylyl Cyclase.
Cell 68: 479-489
Citations 390
3) P. G. Feinstein, K. Shrader, H. A. Bakalyar, W. J. Tang, J. Krupinski, A. G. Gilman, and R .R. Reed (1991)
Molecular Cloning and Biochemical Characterization of a Ca++/Calmodulin Insensitive Adenylate Cyclase from Rat Brain.
PNAS 88(22):10173-10177
Citations 260
2) J. Krupinski, F. Coussen, H. A. Bakalyar, W. J. Tang, P. G. Feinstein, K. Orth, C. Slaughter, R. R. Reed, and A. G. Gilman (1989)
Amino Acid Sequence of an Adenylyl Cyclase Suggests a Channel- or Transporter-Like Structure.
Science 244:1558-1564
Citations 663
1) J. Pevsner, R.R. Reed, P.G. Feinstein, and S.H. Snyder(1988)
Molecular Cloning of Odorant-Binding Protein: Member of a Ligand Carrier Family.
Science 241:336-339
Citations 219
Paul Feinstein