Skip to main content
  • Information for
    • Students
    • Alumni & Friends
    • Faculty
    • Staff
    • Community
  • QUICK LINKS
  • DIRECTORY
  • APPLY
  • GIVE
  • RENT
Hunter College
About
  • Overview
  • Mission
  • Strategic Plan
  • Accreditation
  • Fast Facts
  • Office of the President
  • Capital Projects & Planning
  • Sustainability
  • Campus Information
  • Contact Us
Academics
  • Approach
  • Provost
  • Schools
  • Departments & Programs
  • Majors
  • Honors & Scholars
  • Education Abroad
  • Advising
  • Research & Creative Works
  • Course Catalogs
Admissions
  • Overview
  • Undergraduate
  • Graduate
  • Course Catalogs
Student Life
  • Clubs & Organizations
  • Residence Life
  • Athletics
  • Dining On Campus
  • Community
  • Events
  • News
  • Libraries
Hunter College Schools
  • School of Arts & Sciences
  • School of Education
  • School of Health Professions
  • Hunter-Bellevue School of Nursing
  • Silberman School of Social Work
More Schools
  • Hunter College Campus Schools
  • Hunter College Continuing Education
  • Libraries
  • Students
  • Alumni & Friends
  • Faculty
  • Staff
  • Community
  • Events
  • News
  • APPLY
  • GIVE
  • RENT
  • QUICK LINKS
  • DIRECTORY
News / Chemistry Department News /

Congratulations to Professor Braunschweig for his recent paper in Chemistry – A European Journal

January 2, 2020
Share
receptor abstract

Synthetic carbohydrate receptors could serve as agents for disease detection, drug delivery, or even therapeutics, however, they are rarely used for these applications because they bind weakly and with a preference towards the all‐equatorial glucosides that are not prevalent on the cell surface. Herein the binding of 8 receptors with 5 distinct octyloxy pyranosides, which was measured by mass spectrometry and by 1H NMR titrations in CD2Cl2 at 298 K, is reported, providing binding affinities that vary from ≈101–104 m−1. Although the receptors are promiscuous, 1 shows selectivity for β‐Man at a ratio of 103:1 β‐Man:β‐Gal, receptors 2–4 and 6 have preference for α‐Man, 5 is selective for β‐Gal, and 10 prefers α‐Glc (Man=mannose; Gal=galactose, Glc=glucose). A variety of 1D and 2D NMR, and computational techniques were used to determine the thermodynamic binding parameters (ΔHo and ΔSo) and the structure of the host–guest complex, revealing that dimeric receptor 10 binds β‐Man with increased enthalpy, but a larger entropic penalty than 1. The first‐principles modelling suggests that 10⋅β‐Man forms an inclusion‐type complex where the glycan engages both monomeric subunits of 10 through H‐bonding and C−H⋅⋅⋅π interactions. Like natural glycan‐binding proteins, these receptors bind pyranosides by accessing multivalent and cooperative interactions, and these studies suggest a new approach towards biomimetic synthetic carbohydrate receptors, where conformational flexibility and promiscuity are incorporated into design.

Read the Full Paper at Wiley Online Library
PreviousNext

Office of Communications
for media information and more
student watching online event
Hunter on Demand

Enjoy virtual lectures, discussions and readings by members of Hunter’s distinguished faculty.

Join Us

Follow Us

  • Facebook
  • Twitter
  • Instagram
  • Flickr

NEWS SPOTLIGHT

July 1, 2025
Manoj Pardasani Officially Named Hunter College Provost

Manoj Pardasani appointed as Hunter College’s provost and senior vice president of academic affairs and student success.

July 1, 2025
Two at Hunter Inducted Into the American Academy of Nursing

Two faculty members of the Hunter-Bellevue School of Nursing have been selected as fellows of the prestigious American Academy of Nursing. 

See All Spotlight News

HUNTER

Hunter College
695 Park Ave NY, NY 10065
(212) 772-4000

  • Facebook
  • Twitter
  • Instagram
  • Flickr
  • ABOUT
  • ACADEMICS
  • ADMISSIONS
  • EVENTS
  • NEWS
Hunter College Schools
  • School of Arts & Sciences
  • School of Education
  • School of Health Professions
  • Hunter-Bellevue School of Nursing
  • Silberman School of Social Work
  • School of Arts & Sciences
  • School of Education
  • School of Health Professions
  • Hunter-Bellevue School of Nursing
  • Silberman School of Social Work
Our Other Schools
  • Hunter College Campus Schools
  • Hunter College Continuing Education
  • Hunter College Campus Schools
  • Hunter College Continuing Education
Hunter College Libraries
More Info
  • Bookstore
  • Contact Us & Feedback
  • Jobs
  • Public Safety
  • Roosevelt House
  • Student Housing
  • Space Rentals
  • Bookstore
  • Contact Us & Feedback
  • Jobs
  • Public Safety
  • Roosevelt House
  • Student Housing
  • Space Rentals
Public Information
  • Annual Security & Fire Safety Report
  • Consumer Information
  • CUNY Tobacco Policy
  • Enough is Enough
  • Focus on Campus
  • Annual Security & Fire Safety Report
  • Consumer Information
  • CUNY Tobacco Policy
  • Enough is Enough
  • Focus on Campus
CUNY
  • © 2025 Hunter College
  • Accessibility
  • Privacy
  • Terms