Quality Of Life After Endometrial Cancer: Which Patients Require Additional Support
Andrew Belfiglio, BS1; Erin K. Tagai, PhD1, MPH; Suzanne M. Miller, PhD1; Gina M. Mantia-Smaldone, MD2; Christina S. Chu, MD2
1Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA; 2Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA
Endometrial cancer is the most common cancer of the female reproductive organs. Almost 60,000 new cases will be diagnosed in 2020 in the United States. Endometrial cancer survivors with overweight or obese body mass index (BMI) are at greater risk of comorbidities and, possibly, cancer recurrence; however, extant literature has not yet evaluated quality of life (QoL) during survivorship among this population. The aim of the current study was to identify patient characteristics associated with QoL after active treatment among endometrial cancer survivors with an overweight/obese BMI.
Endometrial cancer survivors with an overweight/obese BMI (N=100) completed a cross- sectional survey after completion of active treatment. Patient-reported measures included demographics; health literacy; protective health behaviors (e.g., physical activity, nutrition); health status and comorbidities; and QoL (physical, social, emotional, functional, and endometrial cancer-specific well-being). Additional medical variables (e.g., grade, stage, BMI) were collected through medical chart review. Multivariable linear regression was completed to identify factors associated with QoL.
Comorbidities and greater BMI were negatively associated with QoL (ps<.01). Greater BMI was also negatively associated with endometrial cancer-specific QoL (p<.05). Additionally, Hispanic/Latinx survivors reported worse endometrial cancer-specific QoL compared to Non-Hispanic White survivors (p<.05).
Our findings suggest overweight/obese endometrial cancer survivors with higher BMI, more comorbidities, or of Hispanic/Latinx ethnicity report worse QoL during survivorship and may benefit from additional psychosocial management. In future research, it will be important to more finely assess and address QoL in overweight/obese endometrial cancer.
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