David Mootoo

David R. Mootoo received a BS and MS from the University of the West Indies and a PhD from the University of Maryland. He did his postdoc research at Duke University. At Hunter, he teaches courses in organic, synthetic and carbohydrate chemistry. His research centers on the design, synthesis and biological properties of small molecules that may interdict in disease-related carbohydrate pathways.

• The University of West Indies (B.S.)
• The University of West Indies (M.S.)
• University of Maryland (Ph.D. 1986)
• Duke University (Postdoc, 1987-1989)

Courses taught have included:

• CHEM 22200  Organic Chemistry 1
• CHEM 22400  Organic Chemistry II
• CHEM 32200  Organic Chemistry III
• CHEM 75100  Advanced Organic Chemistry II – Synthetic Organic
• CHEM 85900  Carbohydrate Chemistry

Research Focus

• Bioorganic Chemistry
• Biochemistry
• Organic Chemistry

Research Statemenet

Our research centers on the design, synthesis and biological properties of small molecules that may interdict in disease-related carbohydrate pathways. Representative projects are methods for broad-based synthesis of tailored glycomimetics, and applications of immuoactive glycolipids, carbohydrate-based antiviral agents and tumor targeting cytotoxic agents.

• Ban, Y.; Dong, W.; Zhang, L.; Zhou, T.; Altiti, A. S.; Ali, K.; Mootoo, D. R.; Blaho V. A.; Hla, T.; Ren, Y.; Ma, X. Abrogation of endogenous glycolipid antigen presentation on myelin-laden macrophages by D-sphingosine ameliorates the pathogenesis of experimental autoimmune encephalomyelitis. Front. Immun. 2019, 10, 404. DOI: 10.3389/fimmu.2019.00404
• Valles, D. J.; Naeem, Y.; Carbonell, C.; Wong, A. M.; Mootoo, D. R.; Braunschweig, A. B. Maskless photochemical printing of multiplexed glycan microarrays for high-throughput binding studies. ACS Biomater. Sci. Eng. 2019, 5, 3131-3138. DOI: 10.1021/acsbiomaterials.9b00033
• Altiti, A. S.; Mootoo, D. R. Synthesis of C-glycoinositols from C-glycosylcrotylstannanes. J. Org. Chem.
  2018, 16, 6534-6540. DOI:DOI: 10.1021/acs.joc.8b00845
• Altiti, A.; Bachan, S.; Mootoo, D. R. The crotylation way to glycosphingolipids: Synthesis of analogues of KRN7000. Org. Lett, 2016, 18, 4654-4657. DOI: 10.1021/acs.orglett.6b02284
• Altiti, A. S.; Bachan, S.; Alrowhani, W.; Mootoo, D. R. An organocatalytic strategy for the stereoselective synthesis of C-galactosides with fluorine at the pseudoanomeric carbon. Org. Biomol. Chem. 2015, 13, 10328-10335. DOI:10.1039/c5ob01471a
• Altiti, A. S.; Mootoo, D. R. Intramolecular nitrogen delivery for the synthesis of C-glycosphingolipids. Application to the C-Glycoside of the immunostimulant KRN7000. Org. Lett, 2014, 16, 1466-1469. DOI: 10.1021/ol5002686
• Garg, H.; Francella, N.; Tony, K. A.; Augustin, L. A.; Fantini, J.; Barchi Jr, J. J.; Puri,
• A.; Mootoo, D. R.; Blumenthal, R. Glycoside analogues of α-galactosylceramide, a novel class of small molecule antiviral agents that inhibit HIV-1 entry. Antiviral Res. 2008 80, 54-61. DOI: 10.1016/j.antiviral.2008.04.004